Hand-foot syndrome with docetaxel : A five-case series

Chemotherapeutic agents may be associated with maculopapular rashes, hyperpigmentation, nail changes, and an acral erythema known as Bergdorf s reaction, palmoplantardysesthesia (PPE), or hand-foot syndrome (HFS). HFS is a rare cutane-­ous reaction to certain chemotherapeutic agents that can be severe and debilitating and may cause a delay in chemotherapy administration. Docetaxel has been infrequently reported to cause HFS. We report the clinical and histopathological details of five cases that occurred with docetaxel in different modes and timing of administration.