Title of article
In vitro testing of daptomycin plus rifampin against methicillin-resistant Staphylococcus aureus resistant to rifampin
Author/Authors
Khasawneh, Faisal A. King Hussein Cancer Center - Department of Internal Medicine, Jordan , Khasawneh, Faisal A. Tulane Health Sciences Center, USA , Ashcraft, Deborah S. Ochsner Clinic Foundation - Infectious Disease Laboratory, USA , Pankey, George A. Ochsner Clinic Foundation - Infectious Disease Laboratory, USA
From page
1726
To page
1729
Abstract
Objectives: To test for synergy between daptomycin (DAP) and rifampin (RIF) against RIF-resistant methicillin-resistant Staphylococcus aureus (MRSA) isolates.Methods: Synergy testing using time-kill assay (TKA) was performed on 6 clinically, and genetically unique RIF-resistant MRSA isolates. The isolates were identified out of 489 (1.2%) samples collected during April 2003 to August 2006, from patients at the Ochsner Medical Center in New Orleans, Louisiana, United States of America.Results: Synergy testing of DAP plus RIF by TKA showed that 5 isolates were indifferent, but one isolate was antagonistic.Conclusion: Our in vitro study failed to demonstrate synergy between DAP plus RIF, against our RIF-resistant MRSA isolates. Clinical failure of this combination should prompt the clinician to consider antagonism, as one of the potential causes
Journal title
Saudi Medical Journal
Journal title
Saudi Medical Journal
Record number
2680434
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