Title of article
In Vivo Assessments of the Poly(d/l)lactide/Polycaprolactone/Bioactive Glass Nanocomposites for Bioscrews Application
Author/Authors
Esmaeilzadeh ، J. Department of Materials and Chemical Engineering - Esfarayen University of Technology , Hesaraki ، S. Department of Nanotechnology and Advanced Materials - Materials and Energy Research Center (MERC) , Borhan ، S. Department of Materials - Buin Zahra Higher Education Center of Engineering and Technology - Imam Khomeini International University
From page
17
To page
22
Abstract
In the present study, in vivo properties of poly (D/L) lactide (PDLLA)/polycaprolactone (PCL)/bioactive glass nanocomposites (PPB) and PDLLA/PCL blends (PP) were investigated up to six months. The in vivo results from the implants inserted on canine models indicated that the weight losses of PPB and PP were approximately 60 and 70%, respectively. In addition, the average molecular weight of both specimens decreased as a function of grafting times; however, such decrease in trend of blends was more considerable than that in nanocomposites. Moreover, the obtained histological images of the animal model up to six months of implantation distinguished the formation of the new bone within the implanted area, while no osteitis and osteomyelitis or structural abnormality were observed. Overall, the animal in vivo tests results of implants within a period of 180 days confirmed the good biocompatibility among them and appropriate degradation behavior of PPB, hence a proper candidate for Anterior Cruciate Ligament Reconstruction (ACLR) screws.
Keywords
PDLLA , PCL , Bioactive glass nanoparticles , 6 months follow up , Canine Animal Model , Bioscrews
Journal title
Advanced Ceramics Progress
Journal title
Advanced Ceramics Progress
Record number
2683439
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