Title of article
SYNTHESIS AND IN VITRO ANTIVIRAL STUDIES OF BIS (PIVALOYLOXYMETHYL) ESTER DERIVATIVE OF 9-{((PHOSPHONOMETHYL) AZIRIDIN-1-YL)METHYL} ADENINE (PMAMA) AND ANALOGUES
Author/Authors
Abu Sheikha, Ghassan M. Al-Zaytoonah Private University of Jordan - Department of Pharmacy, Amman , Bkhaitan, Majdi M. Al-Zaytoonah Private University of Jordan - Department of Pharmacy, Jordan , Al-Hourani, Rami A. Jordan University - Department of Pharmaceutical Chemistry and Pharmacognosy, Amman , Qaisi, Ali M. Jordan University - Department of Pharmaceutical chemistry and Pharmacognosy, Amman , Loddo, Roberta Universita` di Cagliari - Dipartimento di Biologia Sperimentale, Italy , La Colla, Paolo Universita` di Cagliari - Dipartimento di Biologia Sperimentale, Italy
From page
16
To page
22
Abstract
Bis(pivaloyloxymethyl) ester derivative of 9-{((Phosphonomethyl)aziridin-1-yl)methyl}adenine, (bis POM)PMAMA) (1), is an analogue of adefovir dipivoxil and tenofovir disoproxil. Compounds 2, 3, and 4 were prepared in similar way to 1.They were tested in vitro against a wide range of viruses, in articularly against HIV-1 and hepatitis viruses.
Keywords
Adefovir dipivoxil , Tenofovir disoproxil , HIV.
Journal title
Saudi Pharmaceutical Journal(SPJ)
Journal title
Saudi Pharmaceutical Journal(SPJ)
Record number
2684345
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