Title of article
FREE RADICAL SCAVENGING EFFECT OF PHYLLANTHUS SIMPLEX: IN VITRO AND IN VIVO STUDY
Author/Authors
Kumara, Shikha , Sachdevac, Nikhil Banaras Hindu University - Pharmaceutical Chemistry Research Laboratory, , Institute of Technology - Department of Pharmaceutics, INDIA. , Amir, Mohmad , Kumarb, Amit Centre for Biomedical Engineering - Indian Institute of Technology, INDIA , Singh, Sushil K. Banaras Hindu University - Pharmaceutical Chemistry Research Laboratory, , Institute of Technology - Department of Pharmaceutics, INDIA
From page
55
To page
59
Abstract
The ethanolic extract of Phyllanthus simplex (Euphorbiaceae) was found to contain free and conjugated phenolic compounds and was therefore screened for anti-oxidant activity using in vitro and in vivo experimental models. The extract exhibited a high degree of inhibition on rat brain lipid peroxidation up to 92.01± 0.002% by in vitro method. P. simplex extract also exhibited dose dependent inhibitory effects on lipid peroxidation up to the concentration of 18.7 ìg/ml of brain tissue. In vivo studies using albino rats showed that the plant extract (100mg extract/kg, p.o.) significantly antagonized CCl4 (0.5ml/kg, p.o.) induced increase in malondialdehyde. The in vivo anti-oxidant activity of P. simplex was found to be comparable to that of Vitamin-E (50mg/kg, p.o.), used as standard.
Keywords
Phyllanthus simplex , Anti , oxidant activity , Lipid peroxidation.
Journal title
Saudi Pharmaceutical Journal(SPJ)
Journal title
Saudi Pharmaceutical Journal(SPJ)
Record number
2684349
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