Evaluation the levels of Plasma Interleukins (IL-8, IFN-γ, IL-10) in Preeclamptic Pregnancies

This study is to evaluate plasma levels of several cytokines in preeclamptic pregnancies compared to those of healthy pregnancies. Ninety pregnant women with preeclampsia (37 mild 53 severe) and thirty healthy pregnant women were enrolled in the study. Blood samples were taken and plasma levels of IL-8, IL-10, and IFN-γ were measured by enzyme-linked immunosorbent assay (ELISA). Preeclamptic women and their severe cases but not mild cases had significantly (P 0.05) increased levels of plasma IL-8, and IFN-γ as compared with healthy pregnancies. By contrast, plasma levels of IL-10 was significantly (P 0.05) increased in healthy pregnant women as compared to all groups of preeclampsia. Preeclampsia is associated with an imbalance between pro-inflammatory cytokines (IL-8, IFN-γ) and anti-inflammatory cytokines (IL-10), and these support our suggestion of altered immune response in preeclampsia.