Scientific Letter: Effects of glucose-insulin-potassium solution on acute myocardial infarction outcome in patients received streptokinase according to Killip classes

Acute myocardial infarction (AMI) is associated with a high mortality rate and a large number of complications (1). The AMI mortality rate is directly related to the severity of hemodynamic deterioration and can be reduced by rapid reperfusion with chemical agents or mechanical procedures (2). The main mech- anism of improvement is myocardial salvage (3). However, resto- ration of myocardial function does not depend only on the suc- cess of reperfusion therapy. Glucose-insulin- potassium solution (GIK) was proposed for the first time as a polarizing agent pro- moting electrical stability and protecting heart during AMI (4). Although a meta-analysis of subsequent randomized trials found a 28% reduction of in hospital mortality rates (5), there are controversial reports about the GIK effect in AMI management. The present study aimed to evaluate the effects of GIK on AMI patients received streptokinase and compare its effects on patients with different Killip classes (KC I vs. II /III).