Mean platelet volume may not be related to clopidogrel resistance in patients with acute coronary syndrome

We read with great interest the research article by Uzel et al. (1) published in March issue of The Anatolian Journal of Cardiology 2014;14 : 134-9. about diagnostic accuracy of mean platelet volume (MPV) in prediction of clopidogrel resistance in patients with acute coronary syndrome (ACS). They investigated the relationship between MPV levels and clopidogrel non-responsiveness in 185 patients who had been on clopidogrel therapy for any ACS. They found that MPV was significantly higher in non-responders and they suggested that MPV can be used as an indicator of clopidogrel resistance in patients with ACS. We would like to comment about this study.