Title of article
The Possible Protective Effect of Resveratrol on DiazinonInduced Oxidative Stress and Hepatic Injury
Author/Authors
Mehri ، Fereshteh Nutritional Health Research Center - Hamadan University of Medical Sciences , Goodarzi ، Mohammad Taghi Department of Biochemistry - Islamic Azad University, Shahrood Branch , Esfahani ، Maryam Nutritional Health Research Center - Hamadan University of Medical Sciences
From page
44
To page
48
Abstract
Diazinon, one of the most known organophosphate pesticides (OPs), has harmful effects on human organs. Acetylcholinesterase inhibition, oxidative stress, and inflammation are the major mechanisms of diazinon toxicity. Diazinon has several toxic effects on the liver. Resveratrol (RES) is a natural polyphenol compound with antitumor, anti-diabetic, anti-obesity, anti-oxidant, anti-aging, and anti-inflammatory effects. This compound can inhibit lipid peroxidation, protein oxidation, and DNA damage. Moreover, it can induce sirt-1, PI3K/AKT, and HO-1 pathways (negative regulators of inflammatory pathways). A large body of evidence indicated that resveratrol can attenuate liver damage by organophosphates. In this short review, we discuss the significant role of this phytoestrogen and antioxidant against the hepatotoxic effect of diazinon as an OP. With elucidation of the role of this supplement in reducing harmful effects of diazinon, it can be used as a protective agent in people at risk of adverse effects of diazinon
Keywords
Diazinon , Oxidative stress , Inflammation , Liver , Toxicity , Resveratrol
Journal title
Avicenna Journal of Medical Biochemistry
Journal title
Avicenna Journal of Medical Biochemistry
Record number
2695795
Link To Document