Title of article
Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review
Author/Authors
Yarahmadi ، Amir Department of Biochemistry - School of Medicine, Transplant Research Center - Shiraz University of Medical Sciences , Azarpira ، Negar Transplant Research Center - Shiraz University of Medical Sciences , Mostafavi-Pour ، Zohreh Department of Biochemistry - School of Medicine, Autophagy Research Center - Shiraz University of Medical Sciences
From page
181
To page
188
Abstract
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine-protein kinase that senses and combines various environmental signals to regulate the growth and homeostasis of human cells. This signaling pathway synchronizes many critical cellular processes and is involved in an increasing number of pathological conditions such as diabetes, cancer, obesity, and metabolic syndrome. Here, we review different complications of diabetes that are associated with mTOR complex 1 imbalance. We further discuss pharmacological approaches to treat diabetes complications linked to mTOR deregulation.
Keywords
Diabetes , complications , mTOR , mTOR complex 1 , signaling
Journal title
International Journal of Molecular and Cellular Medicine(IJMCM)
Journal title
International Journal of Molecular and Cellular Medicine(IJMCM)
Record number
2697564
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