• Title of article

    Quantitation of CD4+/CD25+/high/CD127low/- Regulatory T-cells in Rheumatoid Arthritis Patients

  • Author/Authors

    Delavari, Samaneh Department of Immunology - School of Medicine - Ahvaz Jundishapur University of Medical Sciences - Ahvaz, Iran , Ghafourian, Mehri Department of Immunology - School of Medicine - Ahvaz Jundishapur University of Medical Sciences - Ahvaz, Iran , Rajaei, Elham Department of Internal Medicine - School of Medicine - Ahvaz Jundishapur University of Medical Sciences - Ahvaz, Iran , Mowla, Karim Department of Internal Medicine - School of Medicine - Ahvaz Jundishapur University of Medical Sciences - Ahvaz, Iran , Ghadiri, Ata Department of Immunology - School of Medicine - Ahvaz Jundishapur University of Medical Sciences - Ahvaz, Iran

  • Pages
    9
  • From page
    179
  • To page
    187
  • Abstract
    Rheumatoid arthritis (RA) is the most common rheumatoid disease of unknown etiology, determined by the articular cartilage destruction and bone loss. The hallmark of RA is the defect in immune tolerance. Regulatory T cells (Treg) play a critical role in the protection of peripheral tolerance. Objective: To assess the percentage of CD4+/CD25+/high/ CD127low/- Treg cells in peripheral blood of RA patients as compared with the healthy individuals. Methods: The number of CD4+/CD25+/high/CD127low/- Treg cells was assessed by multicolor flow cytometry. The clinical disease activity of RA patients was determined by disease activity score 28 (DAS- 28). The correlations of DAS-28 and erythrocyte sedimentation rate (ESR) with Treg cells were evaluated. Results: The percentage of CD4+/CD25+/high/CD127low/- Treg cells in peripheral blood of RA patients significantly decreased as compared with the healthy individuals (P= 0.0002). The percentage of CD4+/ CD25+/high/CD127low/- Treg cells negatively correlated with DAS-28 and ESR. Conclusion: This study concludes that the defect of Treg cells plays a vital role in the pathogenesis of this disease. Further studies are necessary to determine the role of Treg cells in the clinical course of rheumatoid arthritis
  • Keywords
    Rheumatoid Arthritis , Regulatory T Cells , Flow Cytometry , DAS-28
  • Journal title
    Iranian Journal of Immunology (IJI)
  • Serial Year
    2021
  • Record number

    2701538

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2701538