Green synthesis of oxazine derivatives using in situe production of isoquinoline and Cu@KF/CP NPs

An efficient synthesis of oxazine derivatives via one-pot reactions between acetylenic esters, arylisocyanates, phthalaldehyde and ammonium acetate in the presence of Cu@KF/CP NPs as a high performance catalyst in water at room temperature.is described. In addition, for investigation of antioxidant ability radical trapping by DPPH and reducing power of ferric ion experiments was performed. As a result, synthesized compounds show excellent radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media and easy separation of product and catalyst.