Fe3O4-MNPs promoted green synthesis of thiazole derivatives using alkyl bromides

In this research, magnetic iron oxide nanoparticles (Fe3O4-MNPs) were produced using green biosynthetic method by reduction of ferric chloride solution with Clover Leaf water extract. The nanoparticles generated using this procedure can potentially important in different purposes such as organic synthesis. A one-pot, efficient and high yielding procedure for the synthesis of thiazole derivatives is investigated. The procedure carried out via multicomponent reaction of isothiocyanate, alkyl bromides, N-methylthiazole and triphenylphosphine in the presence of bio-Fe3O4-MNPs as catalyst under solvent-free conditions at 50 oC. Easy, simple, rapid and clean procedure for the synthesis of thiazole derivatives are the advantages of this study.