Green synthesis and investigation of antioxidant ability of new phosphonate derivatives

A novel and efficient procedure for the generation of phosphonate derivatives employing catalyst free the reaction of 2-hydroxyacetophenone, isatin or its derivatives, primary amines, dialkyl acetylenedicarboxylates, trimethyl phosphite or triphenyl phosphite and acidic solution of hydrogen peroxide in aqueous media at ambient temperature under ultrasonic irradiation was investigated. Without ultrasonic irradiation the reaction isn’t performed and mixture of reaction is very busy. In addition, the power of some prepared compounds as antioxidant was studied using trapping of radical by DPPH (diphenyl-2-picrylhydrazyl) and ferric reduction activity potential (FRAP) experiment. Some advantages of this procedure are: short time of reaction, high yields of product, easy separation of products.