Title of article
Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice
Author/Authors
Coeto Neitzke-Abreu, Herintha Universidade Estadual de Maringá, Maringá, Brazil , Carlos Souza Caetano, Rhuan Universidade Federal da Grande Dourados, Dourados, Brazil , Rosi Reinhold- Castro, Kárin Universidade Estadual de Maringá, Maringá, Brazil , Sebastião da Costa Lima-Junior, Manoel Department of Immunology - Aggeu Magalhães Institute - Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil , José Tenório dos Santos, Wagner Department of Immunology - Aggeu Magalhães Institute - Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil , de Alcantara Nogueira de Melo, Gessilda Departament of Clinical Analysis and Biomedicine - Universidade Estadual de Maringá, Maringá, Brazil , Kenji Nakamura Cuman, Roberto Universidade Estadual de Maringá, Maringá, Brazil , Mara Alessi Aristides, Sandra Universidade Estadual de Maringá, Maringá, Brazil , Gomes Verzignassi Silveira, Thais Universidade Estadual de Maringá, Maringá, Brazil , Valdrinez Campana Lonardoni, Maria Universidade Estadual de Maringá, Maringá, Brazil
Pages
9
From page
567
To page
575
Abstract
Background: We aimed to determine the cellular recruitment (leukocyte rolling
and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis,
and L. (Leishmania) major species in the mesenteric microcirculation of
BALB/c mice.
Methods: Five experimental groups were considered: group 1 (L. braziliensis);
group 2 (L. amazonensis); group 3 (L. major); group 4 (control group with PBS);
group 5 (negative control group), analyzed 3, 6, 12, and 24 h after parasite inoculation.
Results: Infections by the different Leishmania species caused an increase in the
number of rolling leukocytes: L. braziliensis a peak at 6 h; L. amazonensis and L. major
a peak at 3 h. The Leishmania infections induced leukocyte adhesion: L. major
and L. amazonensis showed an increase after 3 and 6 h, respectively.
Conclusion: The kinetics of cellular recruitment in Leishmania infections, leading
to infection susceptibility or resistance, indicates that distinct mechanisms regulate
the initial response to Leishmania infection and determine its course.
Keywords
Leishmania , Rolling , Cellular adhesion , Leukocyte
Journal title
Iranian Journal of Parasitology (IJP)
Serial Year
2021
Record number
2703487
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