Sulfated polysaccharide coated BaFe12O19: A magnetically separable bifunctional catalyst for the synthesis of benzopyranopyrimidines derivatives and its antibacterial activity evaluation

Marine sulfated polysaccharide Irish moss (IM) coated BaFe12O19 nanocomposites were synthesized and characterized by Fourier Transform Infrared Spectrometer (FT-IR), scanning electron microscope (SEM (, X-ray diffraction (XRD (, vibrating-sample magnetometer (VSM (, and thermal gravimetric analysis (TGA). The indisputable privilege of BaFe12O19@ IM as a recyclable acid-base bifunctional catalyst has been studied in the preparation of benzopyranopyrimidines via a pseudo-four-component reaction of salicylic aldehydes, malononitrile, and various amines. Catalytic amount of BaFe12O19@IM shown high catalytic activity, and stability with negligible detriment in in its efficiency over five catalytic cycle. The catalytic property–catalytic performance associations clearly showed the synergistic effect between Irish moss, as major active phase, and barium ferrite nanoparticles enabling the catalyst separation in a magnetic field. Along with the catalytic activity, a study on the antibacterial performance of BaFe12O19@IM nanocomposites on bacteria strain was evaluated. The results showed that the prepared nanocomposites possess antibacterial activity against Gram-positive Staphylococcus aureus (S. aureus).