synthesis and characterization of heterocyclic compounds derived from 2-mercaptobenzothiozole and study of their biological activities

in this study, schiff base derivatives were reacted with phenyl isothiocyanate and chloroacetic acid to give diazetidine-2-thione and oxazolidinone derivatives. the schiff base derivatives containing the 2-mercabto benzothiazole moiety were obtained via reaction of a different aromatic aldehyde with 2-(benzothiazol-2-ylthio) acetohydrazide. furthermore, 2-(benzothiazol-2-ylthio) acetohydrazide were obtained via reaction of 2-mercabto benzothiazole with ethyl chloroacetate, then with hydrazine hydrate. the newly synthesized compounds were characterized via spectral data (ft-ir and 1h-nmr). the antibacterial activity was studied against examples of gram-positive and gram-negative bacteria.