Antibacterial activity of Streptomyces spp. against extended spectrum beta lactamase bacilli isolated from Urine samples

Twenty soil samples were collected from Hilla city to detect Streptomyces spp. isolates. Cultural characteristics of isolates showed that, all isolates were gram positive, grey aerial mycelium, and yellow-green substrate mycelium when cultured on Yeast Malt Dextrose agar. Escherichia coli producing ESBL were detected. Antibacterial activity of Streptomyces spp. isolates against ESBL E.coli isolates was recoded. The results showed that Streptomyces spp.2 was most active against ESBL isolates with inhibition zone 16 mm against ESBL.1 and 12 mm against ESBL.2. Streptomyces spp.2 was selected for extraction of antibacterial agent .The antimetabolite crude was extracted. Results showed that the crude extract of Streptomyces spp.2 was had antibacterial activity against ESBL isolates with inhibition zone 18 mm against ESBL.1 and 15 mm against ESBL.2