Title of article
Urokinase – type Plasminogen Activator System in Human Breast Cancer
Author/Authors
Al-Jubouri, Reyadh Salim Tikrit University - College of Science - Department of Biology, Iraq , Al-Rawi, Faeza Aftan AlIraqia University - Ibn-Sina College of Medicine, Iraq , Al-Khafaji, Ali Hussien Ministry of Health - Central Public Health Laboratory, Iraq
Pages
7
From page
1050
To page
1056
Abstract
Urokinase plasminogen activator (uPA), urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1(PAI-1) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumors. This study revealed direct correlation between immunohistochemical expression of uPA with pathological stage. No significant association of immunohistochemical expressions of uPA, uPAR and PAI-1 with immunohistochemical expressions for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor -2 (HER-2/neu), and direct association between immunohistochemical expressions of (uPA and uPAR) as well as between immunohistochemical expressions of (uPA and PAI-1).
Keywords
Breast cancer , uPA , uPAR , PAI , Tissue microarray
Journal title
Iraqi Journal Of Science
Serial Year
1400
Journal title
Iraqi Journal Of Science
Record number
2711312
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