Title of article
A Simple, High Yield Route to cis-4-(N-Alkylamino)-L-Prolines
Author/Authors
Curran, Timothy P. Trinity College - Department of Chemistry, USA , Curran, Timothy P. College of the Holy Cross - Department of Chemistry, USA , Marques, Kevin A. Trinity College - Department of Chemistry, USA , Bilimoria, Segufta I. College of the Holy Cross - Department of Chemistry, USA
From page
15
To page
17
Abstract
Reaction of 1 equivalent of N-α-acetyl-cis-4-azido-L-proline with 1 equivalent of an aldehyde and acatalytic amount of Pd-C under an H2 atmosphere cleanly and efficiently yields the corresponding N-α-acetylcis-4-(N-γ-alkylamino)-L-proline derivative.
Keywords
Aminoproline , reductive amination , azide , aldehyde , secondary amine
Journal title
letters in organic chemistry
Journal title
letters in organic chemistry
Record number
2717796
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