Title of article
Chemical and Stereochemical Aspects of Oxidative Coupling of H-Phosphonateand H-Phosphonothioate Diesters. Reactions with N,N-, N,O-and O,O-Binucleophiles
Author/Authors
Nilsson, Johan Stockholm University - Arrhenius Laboratory - Department of Organic Chemistry, Sweden , Kraszewski, Adam Polish Academy of Science - Institute of Bioorganic Chemistry, Poland , Stawinski, Jacek Stockholm University - Arrhenius Laboratory - Department of Organic Chemistry, Sweden , Stawinski, Jacek Polish Academy of Science - Institute of Bioorganic Chemistry, Poland
From page
188
To page
197
Abstract
Efficient protocols for oxidative coupling of dinucleoside H-phosphonate and dinucleoside H-phosphonothioate diesters with 6-aminohexan-1-ol, hexane-1,6-diamine, and hexane-1,6-diol, promoted by iodine were developed. In the instance of coupling with O-nucleophiles, the presence of t-butyldiphenylsilyl chloride and excess of iodine during oxidative coupling were found to have beneficial effect for these reactions in terms of rates and purity of the formed products.
Keywords
H , phosphonates , H , phosphonothioates , binucleophiles , oxidative coupling
Journal title
letters in organic chemistry
Journal title
letters in organic chemistry
Record number
2717823
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