Title of article
Advances in 1,3-Dipolar Cycloaddition Reaction of Azides and Alkynes – APrototype of “Click” Chemistry
Author/Authors
Wang, Qian University of South Carolina - Department of Chemistry and Biochemistry, USA , Chittaboina, Srinivas University of South Carolina - Department of Chemistry and Biochemistry, USA , Barnhill, Hannah N. University of South Carolina - Department of Chemistry and Biochemistry, USA
From page
293
To page
301
Abstract
Click chemistry, designated by Sharpless and his coworkers, is a modular approach that uses onlythe most practical and reliable chemical transformations. The Huisgen reaction, especially the newly developed copper(I)-catalyzed 1,2,3-triazole formation reaction between azides and alkynes, is regarded as the “cream of the crop” of click chemistry. In this review, we introduce the recent development of this reaction, and highlight some of its important applications in drug discovery, bioconjugation chemistry, materials development and surface modification.
Journal title
letters in organic chemistry
Journal title
letters in organic chemistry
Record number
2717852
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