Title of article
The Natural Amino Acid Derived Chiral Sulfonamide Ligands in the Catalytic Asymmetric Addition of Phenylacetylene to Aldehydes
Author/Authors
Han, Zhi-jian Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China , Daa, Chao-shan Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China , Qiu, Li Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China , Ni, Ming Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China , Zhou, Yi-feng Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China , Wang, Rui Chinese Academy of Sciences - Lanzhou Institute of Chemical Physics - State Key Laboratory for Oxo Synthesis and Selective Oxidation, China , Wang, Rui Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China
From page
143
To page
148
Abstract
Several simple amino acids derived chiral sulfonamide ligands were synthesized in simple three steps. When we used these ligands in the asymmetric addition of phenylacetylene to aldehydes, the corresponding propargylic alcohols were isolated with good yields. The highest ee value was obtained up to 99%. The results proved that the backbone of the chiral source greatly influenced the enantioselectivity.
Keywords
Sulfonamide alcohol, asymmetric addition , phenylacetylene, aldehyde
Journal title
letters in organic chemistry
Journal title
letters in organic chemistry
Record number
2717966
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