Title of article
A Silica-Supported Copper(I) Catalyzed Sonogashira Coupling Reaction
Author/Authors
Zhang, Liyuan Huaibei Coal Teachers College - Department of Chemistry, China , Li, Pinhua Huaibei Coal Teachers College - Department of Chemistry, China , Wang, Lei Huaibei Coal Teachers College - Department of Chemistry, China , Wang, Lei Chinese Academy of Sciences - Shanghai Institute of Organic Chemistry - State Key Laboratory of Organometallic Chemistry, China
From page
282
To page
285
Abstract
An immobilization of copper(I) in organic–inorganic hybrid materials catalyzed Sonogashira coupling reaction was developed. Terminal alkynes reacted with aryl iodides and aryl bromides in the presence of 3-(2-aminoethylamino)propyl functionalized silica gel immobilized copper(I) catalyst, triphenylphosphineand potassium carbonate in DMF. The reactions generated the corresponding cross-coupling products in goodto excellent yields. Furthermore, silica-supported copper was recovered and recycled by a simple filtration ofthe reaction solution and used for six consecutive trials without decreases in activity.
Keywords
Sonogashira coupling reaction , organic–inorganic hybrid material , immobilization of copper(I) , heterogeneous catalyst
Journal title
letters in organic chemistry
Journal title
letters in organic chemistry
Record number
2717996
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