Title of article
PROKINETIC EFFECT OF CLARITHROMYCIN AND AZITHROMYCIN – IN VITRO STUDY ON RABBIT DUODENUM
Author/Authors
CHIRAGH, SADIA King Edward Medical University - Department of Pharmacology, Pakistan , CHIRAGH, SADIA Fatima Jinnah Medical College, Pakistan , BEGUM, ALMAS King Edward Medical University - Department of Pharmacology, Pakistan , BEGUM, ALMAS Fatima Jinnah Medical College, Pakistan , KARIM, SAMINA King Edward Medical University - Department of Pharmacology, Pakistan , KARIM, SAMINA Fatima Jinnah Medical College, Pakistan
From page
130
To page
134
Abstract
There is a continuous search for new prokinetic agents for use in gastro intestinal hypomotility. Erythromycin, a macrolide, is one of them. In this study we observed effect of other macrolides, i.e. clarithromycin and azithromycin on rabbit duodenum and compared with that of neostigmine. Both these drugs produced significant prokinetic effect with EC50 0.4 ,g/ml and 0.29 ,g/ml respectively. Effect of clarithromycin was well sustained as compared to that of azithromycin, so it seemed to be a better prokinetic agent
Journal title
BioMedica
Journal title
BioMedica
Record number
2718802
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