DIFFERENTIAL PRESERVATION OF RABBIT KIDNEY AND LIVER TISSUE IN RINGER LACTATE, EURO COLLINS AND UNIVERSITY OF WISCONSIN SOLUTIONS

Formalin, the most widely used preservative, has certain drawbacks. The foremost of them is interference with immunohistochemistry. To evaluate the efficacy of three commonly used organ preservation solutions for tissue preservation this experimental study was carried out on rabbit kidney and liver The tissue slices were stored in Ringer Lactate, Euro Collins and University of Wisconsin solutions (UW solution), for various fixed time intervals. The three solutions were used in their original form as well as with addition of antimicrobial agents. Morphological preservation was assessed by a semi quantitative method. Kidney slices showed better morphological preservation than liver tissue. UW solution demonstrated the highest preservation of the three solutions tried. UW solution was especially effective for liver pre- servation. Addition of anti microbial agents was more beneficial to kidney preservation than liver. Thus it was concluded that organ preservation solutions may be used for tissue pre- servation as well.