Hardy-Weinberg equilibrium and association study of insertion/deletion polymorphism of ACE gene and Alzheimer s disease in Egyptian patients

I read with interest the recent article entitled ‘‘Association of insertion/deletion polymorphism of ACE gene and Alzheimer’s disease in Egyptian patients’’ by Hassanin et al. [1]. The authors investigated whether insertion/deletion polymorphism (dbSNP rs1799752) of the angiotensin converting enzyme (EC 3.4.15.1; ACE; OMIM: 106180) was associated with the risk of Alzheimer’s disease in Egyptian patients. The authors reported that their findings support the hypothesis of implication of the I (insertion) allele in the development of Alzheimer’s disease [1]. However, I would like to make a few comments about the study.