Histological study on effect of Solanum nigrum dried fruits extract on induced stomach ulcers in experimental rats

The antiulcerogenic effect of S. nigrum dried fruits extract on aspirin induced stomach ulcers has been clarified. Aspirin was found to cause stomach erosion, mucosal injury, haemorrhage, infiltration of inflammatory cells and an increase in gastric pits depth. In addition to degenerated parietal and chief cells which clearly seen near the muscularis mucosa While the stomach sections related to animals treated with extract and aspirin (400mg/kg. dose) showed mild mucosal injury, little number of congested blood vessels, mild infiltration of leucocytes in submucosa and no haemorrhage. Also an increase in mucus layer thickness which covers the surface mucosal layer, compared with animals treated with aspirin only. The results showed no effect of S. nigrum dried fruits extract on stomach except an increase in mucus layer thickness in all stomach regions and increase in mitotic figures in epithelial cells of mucosal layer in comparison to control. Thus it may be suggested that the S. nigrum extract provides a protective material for stomach mucosa and has an important role in increasing the mucus as suppression for aspirin or other drugs which induce stomach ulcers and increases the regenerative ability of tissue to defence against injury which is caused by drugs.