In vitro release kinetics study of Diallyl Disulphide entrapped into mesoporous silica matrix & evaluation of its antimicrobial activity

Diallyl disulphife (DADS) is one of the major constituents of garlic which have antimicrobial activity as well as many other advantages for human health. Sulpher present in DADS is main the reactive one to deal with the microbes. Mesoporous silica nanomaterial (MSNs) is evaluated as potential drug carrier for any organic drug molecule to keep it intact for in vitro sustained release into body fluids. Comparing between two different body fluids, dissolution rate of DADS is more in SBF (pH 7.4) than SGF (pH 1.2) because of its acidic nature. In two medium the release mechanism is super case II transport as in both cases the ‘n’ value of koresmeyer peppas model is greater than 0.89 obtained through kinetic study. MIC value of DADS against Salmonella typhi is 0.941 mg/ml. Besides this microscopic analysis confirm the deformation of microbial cells. These means mesoporous silica nanomaterial entrapped with DADS and subsequently released in pH 7.4 is much more concerned with high amount of drug availability in body fluids.