Aqueous media preparation of 2-amino-4H-benzopyran derivatives using cerium oxide nanoparticles as a recyclable catalyst

2-amino-4H-benzopyran derivatives have received considerable attention due to their valuable biological and medicinal properties such as anticoagulant, antispasmodic, diuretic, and anti-cancer activities. Benzopyran derivatives have strong relaxing activity on blood vessels, cardiac muscles, and smooth muscles. The present study reports the easy synthesis of 4H-benzopyran derivatives by using aldehyde, malononitrile, and dimedone in the presence of cerium(IV) oxide nanopowder as a nontoxic catalyst. The advantages of this method include catalyst recovery, high efficiency, short reaction time, and ease of operation method.