Correlation between Serum Vitamin D and Calcium Levels in Missed Miscarriage

Pregnancy is considered physiological stress, during which a woman’s normal static metabolism becomes dynamic anabolism and significant changes are observed in biochemical factors. This study aimed to assess the relationship of serum vitamin D and calcium levels in a pregnant woman with a missed miscarriage. A comparison was performed among 160 women, including 80 females with missed miscarriage (as the study group) and 80 pregnant women (as the control group) in the first and second trimester of pregnancy (before the end of the 24th week of the pregnancy). The results of the comparison showed that there was an insignificant change in serum calcium, while there was a significant reduction in serum vitamin D (P≤0.05). It was also revealed that, in comparison to normal controls, there was a significant increase in the ratio of serum calcium/vitamin D ratio in cases of missed miscarriage (P≤0.05). Based on the results of the study, it can be concluded that the estimations of serum vitamin D and calcium/vitamin D ratio in certain pregnancies can be considered valuable parameters in predicting missed miscarriage.