Title of article
Safety and Adverse Events Related to Inactivated COVID- 19 Vaccines and Novavax; a Systematic Review
Author/Authors
Dadras, Omid Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Mehraeen, Esmaeil Department of Health Information Technology - Khalkhal University of Medical Sciences, Khalkhal, Iran , Karimi, Amirali School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Tantuoyir, Marcarious M. School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Afzalian, Arian School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Nazarian, Newsha School of Medicine - Islamic Azad University, Tehran, Iran , Mojdeganlou, Hengameh Department of Pathology - Urmia University of Medical Sciences, Urmia, Iran , Mirzapour, Pegah Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Shamsabadi, Ahmadreza Department of Health Information Technology - Esfarayen Faculty of Medical Sciences, Esfarayen, Iran , Dashti, Mohsen Department of Radiology - Tabriz University of Medical Sciences, Tabriz, Iran , Ghasemzadeh, Afsaneh Department of Radiology - Tabriz University of Medical Sciences, Tabriz, Iran , Vahedi, Farzin School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Shobeiri, Parnian School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Pashaei, Zahra Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Seyed Alinaghi, Ahmad Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran
Pages
14
From page
1
To page
14
Abstract
Introduction: Knowledge of the safety of vaccines is crucial, both to prevent and cure them and to decrease the
public hesitation in receiving vaccines. Therefore, this study aimed to systematically review the adverse events
reported for inactivated vaccines and Novavax. Methods: In this systematic review, the databases of PubMed,
Scopus, Cochrane, and Web of Science were searched on September 15, 2021. Then we identified the eligible
studies using a two-step title/abstract and full-text screening process. Data on the subjects, studies, and types of
adverse events were extracted and entered in a word table, including serious, mild, local, and systemic adverse
events as well as the timing of side effects’ appearance. Results: Adverse effects of inactivated coronavirus vaccines
side effects were reported from phases 1, 2, and 3 of the vaccine trials. The most common local side effects
included injection site pain and swelling, redness, and pruritus. Meanwhile, fatigue, headache, muscle pain,
fever, and gastrointestinal symptoms including abdominal pain and diarrhea were among the most common
systemic adverse effects. Conclusion: This systematic review indicates that inactivated COVID-19 vaccines,
including Sinovac, Sinopharm, and Bharat Biotech, as well as the protein subunit vaccines (Novavax) can be
considered as safe choices due to having milder side effects and fewer severe life-threatening adverse events.
Keywords
Adverse Effects , BBV152 COVID-19 vaccine , COVID-19 , COVID-19 vaccines , recombinant SARS-CoV-2 vaccine NVX-cov2373 , Safety , SARS-CoV-2 , sinovac COVID-19 vaccine , Vaccines , Inactivated
Journal title
Archives of Academic Emergency Medicine (AAEM)
Serial Year
2022
Record number
2730375
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