Wound Healing by Semelil: A Structured Review With a Focus on Diabetic Foot Ulcers

Diabetic Foot Ulcer (DFU) is a common complication of diabetes mellitus. Among the various non-invasive treatment modalities used for the improvement of DFUs healing, topical herbal therapies are regaining an increasing body of interest. In this report, the authors review the literature and discuss wound healing with a focus on DFUs with Semelil. In this Structured review, we searched for articles published between 2008 and 2021, in the international and national databases with keywords “Melilotus officinalis”, “Semelil”, “Angipars”, and “diabetic foot ulcer”, “wound management”. Eligible articles (n=26) were identified according to inclusion and exclusion criteria. This review showed no complications with the application of Semelil and consensus on the positive effects of the found medication. In summary, our review showed that Semelil may be a valuable non-invasive treatment for wound healing in DFUs patients and reduces the wound size for four weeks without major adverse side effects.