Natural products for attenuating Alzheimer’s disease: A narrative review

Alzheimer’s disease (AD) is one of the most common neurodegenerative conditions and a major contributor to dementia in the elderly and its prevalence is rising quickly. There are currently 50 million AD sufferers globally, according to the epidemiological data. The most noticeable signs of AD are nearly nonexistent, and they typically include forgetting of recent events. The development of extracellular Amyloid-beta 42 plaques, intracellular hyperphosphorylated Tau tangles, oxidative overload because of mitochondrial malfunction, and genetic abnormalities are just a few of the mechanisms that contribute to AD. Through temporary palliative therapy, which reduces the rate of cognitive damage linked to AD, the current treatment primarily addresses symptoms. In numerous studies, medicinal plants have been linked to potential anti-AD effects. This review aims to explain the underlying pathways of action of various plant-mediated extracts, plant-secondary metabolites, and herbal remedies preparations tested against AD as published in various preclinical and clinical research studies.