Silica-Imidazole Solid Catalyst for N-Glycine Derivatives Synthesis

Schiff base was reacted with α-chloroacetic acid to produce N-(α-chlorobenzyl)-N-phenylglycine derivatives (N-Gly) over solid heterogeneous catalyst. Different N-Gly derivatives were synthesized over the catalyst with approximately 90% yield. Both calculated and theoretical elemental analyses of N-Gly derivatives were in agreement with each other. The functional groups of N-Gly derivatives were proved by the FT-IR spectroscopy. The melting points N-Gly derivatives were matched with those in the literature. The catalyst was produced by immobilizing sodium silicate from rice husk with 3–(chloropropyl)triethoxysilane followed by refluxed the product with p-xylyl-di-imidazolium chloride. The results showed that the optimum catalyst conditions were 5 h as reaction time, 0.25 g mass of catalyst, 90 °C as reaction temperature, and toluene as the best solvent.