Spectral and Electrochemical Sensing Studies of Novel Tetradentate Schiff Bases, Having Enhanced Antifungal Activity, Containing Ferrocene and Aromatic Moieties Attached Imines

Multi metal ion sensing unsymmetrical Schiff bases containing ferrocene group attached imine at one side and aromatic moiety connected azomethine on the other side have been synthesized. Titration studies coupled with a UV-Visible spectrophotometer expose the binding aptitude of new receptors. Development of MLCT band near 457 nm for the coordination of Cu2+ ions with new ligands is also noticed. Electrochemical studies of receptor solutions with added metal ions expose quasi-reversible processes by giving superfluous ΔEP values (146-161 mV, then the expected 59 mV). The concentration of metal ions required for effective sensing is calculated from the percentage amount of ΔIpa extracted from the Ipa data. Results obtained in computational molecular docking studies and in-vitro analysis invite more focused research by the pharmacist to develop new formulations for antifungal medicines.