Title of article
The Role of High-Fructose Diet in Liver Function of Rodent Models: A Systematic Review of Molecular Analysis
Author/Authors
Mirzaei ، Roya Department of Toxicology and Pharmacology - Faculty of Pharmacy and Pharmaceutical Sciences - Islamic Azad University, Tehran Medical Sciences , Khosrokhavar ، Roya Food and Drug Laboratory Research Center - Food and Drug Administration, MOH ME , Arbabi Bidgoli ، Sepideh Department of Toxicology and Pharmacology - Faculty of Pharmacy and Pharmaceutical Sciences - Islamic Azad University, Tehran Medical Sciences
From page
326
To page
339
Abstract
The present systematic review of animal studies on long-term fructose intake in rodents revealed a significant decrease in the activities of antioxidant enzymes due to a fructose-rich diet. The reduced activity of these enzymes led to an increase in oxidative stress, which can cause liver damage in rodents. Of eight studies analyzed, 5 (62.5%) and 1 (12.5%) used male and female rats, respectively, while 2 studies (25%) used female mice. Moreover, half of the studies used high-fructose corn syrup, but the other half employed fructose in the diet. Hence, it is essential to monitor dietary habits to ensure public health and nutrition research outcomes.
Keywords
Animal model , Fructose , Liver , Liver function tests , Oxidative stress
Journal title
Iranian Biomedical Journal(IBJ)
Journal title
Iranian Biomedical Journal(IBJ)
Record number
2754281
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