The Value of Epidermal Growth Factor Receptor Expression in Predicting Aggressive Behaviors of Bladder Neoplasms

Background: It has been shown that some cancers express the epidermal growth factor receptor (EGFR). Several variables influence bladder cancer prognosis, including stage, grade, and gene expression. Objectives: We used immunohistochemistry to measure the prevalence and prognostic significance of EGFR expression in bladder tumors in our population. Methods: Thirty bladder tumors were the subjects of this cross-sectional study. To evaluate the biological behavior of the tumors, histopathological analysis was performed. We carried out EGFR immunohistochemical staining to evaluate gene expression. Results: EGFR was expressed in 25 (83.3%) patients. Expression of this biomarker was independent of tumor characteristics such as lymphatic invasion, muscle invasion, and tumor grade and stage (P value 0.05). Conclusions: Remembering each patient s tumor characteristics determine that prognosis is crucial. The prognostic value of EGFR expression in predicting aggressive behavior in bladder tumors is marginal, but it is necessary to evaluate therapeutic response.