Title of article
Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review
Author/Authors
Thennakoon ، Sachini M Department of Biomedical Sciences - Faculty of Science - NSBM Green University , Withanage ، Niroshima D Department of Medical Laboratory Sciences - Faculty of Allied Health Sciences - University of Sri Jayewardenepura
From page
243
To page
255
Abstract
The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type 2 diabetes mellitus (T2DM) and the risk of incident T2DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type 2 diabetes mellitus, suggesting GGT as a risk predictor of T2DM. The incidence of type 2 diabetes and its association with GGT elevation could be explained by oxidative stress in cells followed by subclinical inflammation and fatty liver, leading to impaired insulin secretion and insulin resistance. A strong correlation is evident between BMI and GGT, in which hepatic steatosis and insulin resistance are proposed to be the intermediate connecting characteristics.
Keywords
Gamma , glutamyl transferase , Type 2 diabetes mellitus , Body mass index
Journal title
Iranian Journal of Diabetes and Obesity
Journal title
Iranian Journal of Diabetes and Obesity
Record number
2756795
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