Synthesis and Identification of Some New Imidazolidine-4-one, Oxazolidine-4-one and Thiazolidine-4-one Derivatives from Phenidone and Their Antimicrobial and Antioxidant Activities Investigation

The reaction of 1-phenyl-3-pyrazolidone (phenidone) bound to sodium hydride and reacting with chloroacetyl chloride give compound (1) which then reacts with hydrazine hydrate to give compound (2). Compound 2 when reacted with substituted benzaldehydes, produced five derivatives of Schiff’s base (3-7) these derivatives were then introduced into the cyclization process with glycine, 2-chloro acetic acid and 2-mercaptoacetic acid to yield new imidazolidine-4-one, oxazolidine-4-one and thiazolidine-4-one containing 1-pheny-3-pyrazolidone. The newly synthesized compounds were structurally validated using FTIR, 1HNMR, and 13CNMR spectroscopy in vitro studies were conducted to assess the antimicrobial properties and total antioxidant capacity, as well as the reducing power assay for the compounds. The results shown [8, 9 and 14] have good antioxidant activity