Transition Metal Complexes of New Schiff Base Ligand Derived from Boron-based Vanillin with Study of Some of Their Biological and Medical Applications

Synthesis of new Schiff base ligand [(Z)-4-(((1H-1,2,4-triazol-3-yl)imino)methyl)-2-methoxyphenyl dihydrogen borate] (L) by reaction of boron derivative of vanillin ( 4-formyl-2-methoxyphenyl dihydrogen borate) with 3-amino-1,2,4-triazole was carried on in a 1:1 mole ratio. In addition, the complexes of metal Co(II), Ni(II), and Cu(II) were characterized. Each compound was characterized using spectroscopic techniques such as FT-IR, 1H-NMR, and UV-Vis spectrometry. Furthermore, the following analytical techniques were employed: thermal analysis (TG), atomic absorption spectroscopy (AAS), elemental microanalysis (C.H.N), measurements of the melting point, chloride analysis, magnetic sensitivity testing, and molecular conductivity tests. All of the complexes exhibited non-electrolytic behavior and their indicated geometrical shapes were octahedral. All compounds exhibited paramagnetic magnetic characteristics. The synthesized compounds possessed a good efficiency as antimicrobial activity (anti-bacterial and anti-fungal) against Escherichia coli (Gram-negative), Staphylococcus aureus (Gram-positive), and Candida albicans. The synthesized compounds were assessed as an in vitro anti-cancer agent against human thyroid carcinoma (FTCI33), the result showed that the copper complex was more effective compared to ligand and its other complexes.