Title of article
Bacillus coagulans T4 and Lactobacillus paracasei TD3 Ameliorate Skeletal Muscle Oxidative Stress and Inflammation in High-Fat Diet-Fed C57BL/6J Mice
Author/Authors
Shams ، Masoumeh Department of Medical Laboratory Sciences - School of Allied Medical Science - Shahid Beheshti University of Medical Sciences , Esmaeili ، Fataneh Department of Clinical Biochemistry - Faculty of Medicine - Tehran University of Medical Sciences , Sadeghi ، Samira Department of Medical Laboratory Sciences - School of Allied Medical Science - Shahid Beheshti University of Medical Sciences , Shanaki-Bavarsad ، Mahsa Department of Neurology - Memory and Aging Center - University of California San Francisco , Seyyed Ebrahimi ، Shadi Sadat Department of Clinical Biochemistry - Faculty of Medicine - Tehran University of Medical Sciences , Hashemnia ، Mohammad Reza Department of Clinical Biochemistry - Faculty of Medicine - Tehran University of Medical Sciences , Tajabadi-Ebrahimi ، Maryam Department of Biology - Islamic Azad University, Tehran Central Branch , Emamgholipour ، Solaleh Department of Clinical Biochemistry - School of Medicine - Tehran University of Medical Sciences , Shanaki ، Mehrnoosh Department of Medical Laboratory Sciences - School of Allied Medical Science - Shahid Beheshti University of Medical Sciences
From page
1
To page
12
Abstract
Background: This study aims to investigate the effects of Bacillus coagulans T4 and Lactobacillus paracasei TD3 probiotics on skeletal muscle inflammation and oxidative stress in C57BL/6J mice fed a high-fat diet (HFD). Methods: Probiotics B. coagulans T4, andL. paracasei TD3 were administered to male C57BL/6J mice fed withHFD. The gene expression of macrophage infiltration markers, inflammatory cytokines, and oxidative stress indicators in the muscle tissue was investigated. Results: Treatment with B. coagulans T4 and L. paracasei TD3 reduced macrophage infiltration, accompanied by a decrease in the expression of monocyte chemoattractant protein-1 (MCP-1) and an increase in the expression of interleukin (IL)-10. On the other hand, L. paracasei TD3 decreased malondialdehyde (MDA) while B. coagulans T4 decreased carbonyl and increased catalase activity. Conclusions: Treatment with probiotics B. coagulans T4 and L. paracasei TD3 partially ameliorated obesity-induced skeletal muscle inflammation in HFD-fed mice.
Keywords
High , Fat Diet , Skeletal Muscle , Inflammation , Oxidative Stress , Probiotic
Journal title
Iranian Journal of Pharmaceutical Research(IJPR)
Journal title
Iranian Journal of Pharmaceutical Research(IJPR)
Record number
2763310
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