Title of article
Synthesis and Biological Evaluation of New Nitroimidazole Derivatives as Anti-Helicobacter pylori Agents Against Metronidazole-Resistant Strains
Author/Authors
Bayati ، Zahra Department of Pharmaceutical Chemistry - School of Pharmacy - Shahid Beheshti University of Medical Sciences , Amidi ، Salimeh Department of Pharmaceutical Chemistry - School of Pharmacy - Shahid Beheshti University of Medical Sciences , Shahabimehr ، Mahnaz Department of Biology - Faculty of Pharmaceutical Sciences - Islamic Azad University, Tehran branch , Alebouyeh ، Masoud Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Disease - Shahid Beheshti University of Medical Sciences , Mahboubi ، Arash Department of Pharmaceutics - Food Safety Research Center, School of Pharmacy - Shahid Beheshti University of Medical Sciences , Tabatabai ، Abbas Department of Pharmaceutical Chemistry - School of Pharmacy, Phytochemistry Research Center - Shahid Beheshti University of Medical Sciences
From page
1
To page
8
Abstract
Since several Helicobacter pyloristrains have become resistant to metronidazole, new nitroimidazole derivatives based on metronidazole were designed and synthesized with different substituents on imidazole nitrogen. The activity of the synthesized compounds was evaluated against 20 clinically isolated metronidazole-resistant H. pyloristrains. Some synthesized compounds were effective against those metronidazole-resistant H. pyloristrains. Three compounds exhibited the most potent inhibitory activities (MIC 50= 8 µg/mL and MIC 90= 16 µg/mL).
Keywords
Nitroimidazole Derivatives , Metronidazole Resistance , Helicobacter pylori , Synthesis
Journal title
Iranian Journal of Pharmaceutical Research(IJPR)
Journal title
Iranian Journal of Pharmaceutical Research(IJPR)
Record number
2763316
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