Title of article
The effect of exposure to electric fields on EGFR and PDGFR in glioblastoma cell model: In vitro study
Author/Authors
Al Fauzi ، Asra Neurosurgery Department - Faculty of Medicine, Dr. Soetomo General Academic Hospital - Universitas Airlangga , Permana ، Khrisna Rangga Neurosurgery Department - Faculty of Medicine, Dr. Soetomo General Academic Hospital - Universitas Airlangga , Haq ، Irwan Immadoel Neurosurgery Department - Faculty of Medicine, Dr. Soetomo General Academic Hospital - Universitas Airlangga , Parenrengi ، Muhammad Arifin Neurosurgery Department - Faculty of Medicine, Dr. Soetomo General Academic Hospital - Universitas Airlangga , Purwati ، Purwati Stem Cell Research and Development Center, Institute of Tropical Disease - Universitas Airlangga , Utomo ، Budi Department of Public Health - Faculty of Medicine - Universitas Airlangga , Sahudi ، Sahudi General Surgery Department - Faculty of Medicine, Dr. Soetomo General Academic Hospital - Universitas Airlangga , Taruno ، Warsito Purwo C-Tech Labs Edwar Technology
From page
1612
To page
1622
Abstract
The aim of this study was to determine differences in expression of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR)) in glioblastoma cell cultures in vitro when exposed to electric fields. This work followed a true experimental research design with a post-test only control group design. Glioblastoma cell culture was divided into 2 groups, namely the glioblastoma cell culture group exposed to electric field and those that were not exposed. This tool provided a voltage of 10, 30, and 50 peak to peak Voltage (Vpp) with a frequency of 100 KHz alternating current (AC). Evaluation of EGFR and PDGFR expressions was carried out after exposure. Exposure to a weak electric field with medium frequency for 24, 48, and 72 hours decreased the expression of EGFR and PDGFR in the angiogenesis process of glioblastoma cell cultures in vitro but not significantly. Further research is needed with a larger range of doses and treatment duration.
Keywords
Glioblastoma , EGFR , PDGFR , In vitro , Electric fields
Journal title
Eurasian Chemical Communications
Journal title
Eurasian Chemical Communications
Record number
2763750
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