Comparison of Sleeve Gastrectomy and SASI Bypass Surgery Outcomes in Patients with Obesity After Seven Months in Shiraz

Background: Although bariatric surgery has been introduced as a therapeutic option for patients with obesity, there is still debate on the choice of procedure.Objectives: This study aimed to compare two types of bariatric surgeries in patients with obesity: Sleeve gastrectomy (SG) and single anastomosis sleeve ileal (SASI) bypass. Methods: This observational prospective study compares patients with obesity who received either of the two types of bariatric surgeries at Ghadir or Shahid Faghihi hospitals in Shiraz from October 2019 to November 2020. Metabolic profiles, shear wave liver elastography (fibroscan), and cardiac evaluations (echocardiography) were performed at baseline and then seven to eleven months after the surgery. Results: Forty-five patients with obesity who had undergone SG and SASI bypass entered this study. Fasting plasma glucose (FPG) and triglycerides (TG) decreased during the follow-up in both groups (P = 0.032, P 0.001, respectively). The fibrosis score decreased significantly from 6.45 (4.55) before surgery to 5.40 (3.60) after surgery, and the cardiac ejection fraction increased significantly from 61.5% (12.5%) before surgery to 65.0% (8.5%) after surgery following the SASI bypass compared to the SG (P = 0.034, P = 0.008, respectively). Conclusions: Despite the lack of difference in weight reduction, SASI bypass, compared to sleeve gastrectomy, may result in a more rapid improvement in cardiac function and liver fibrosis.