Title of article
Thymoquinone Effects on the Expression of p62 Gene in Cisplatin-Induced Testicular Damage in Mice
Author/Authors
Shojaedini ، Mina , Hemadi ، Masoud Department of Anatomical Sciences - Faculty of Medicine, Infertility and Perinatology Research Center - Ahvaz Jundishapur University of Medical Sciences , Saki ، Ghasem Department of Anatomical Sciences - Faculty of Medicine, Physiology Research Center - Ahvaz Jundishapur University of Medical Sciences , Fakhredini ، Fereshtesadat , Khodayar ، Mohammad Javad Department of Toxicology-Pharmacology - Toxicology Research Center, School of Pharmacy - Ahvaz Jundishapur University of Medical Sciences , Khorsandi ، Layasadat Cellular and Molecular Research Center, Medical Basic Sciences Research Institute - Ahvaz Jundishapur University of Medical Sciences
From page
1
To page
6
Abstract
Background: Cisplatin (CPN) is widely used for the management of various malignant tumors. Objectives: This study investigated the effects of Thymoquinone (TQN) on the expression of the p62 gene in CPN-induced testicular damage in mice. Methods: Histomorphometry, testis injury scores, expression of p62, and protein levels of LC3-II were assessed. Results: Cisplatin induced histological changes, increased p62 expression (P 0.01), and reduced LC3-II levels (P 0.001). Thymoquinone pretreatment decreased p62 expression while increasing LC3-II protein levels. Thymoquinone significantly reversed the testicular injury scores and improved histomorphometric parameters. Conclusions: The results indicate that TQN enhances autophagy and improves testicular tissue in CPN-intoxicated mice.
Keywords
Thymoquinone , Cisplatin , Autophagy , Testis
Journal title
Jentashapir Journal of Cellular and Molecular Biology
Journal title
Jentashapir Journal of Cellular and Molecular Biology
Record number
2766535
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