Title of article
Prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli associated with outbreaks of food-borne gastroenteritis in Tehran
Author/Authors
Soltan Dallal ، Mohammad Mehdi Department of Pathobiology, Division of Medical Microbiology - School of Public Health, Food Microbiology Research Centre - Tehran University of Medical Sciences , Rajabi ، Zahra Food Microbiology Research Centre - Tehran University of Medical Sciences , Papizadeh ، Moslem Department of Recombinant Hepatitis B Vaccine - Production and Research Complex - Pasteur Institute of Iran , Amiri ، Samaneh Department of Pathobiology, Division of Medical Microbiology - School of Public Health - Tehran University of Medical Sciences , Rahimi Foroushani ، Abbas Department of Epidemiology and Biostatistics - School of Public Health - Tehran University of Medical Sciences , Naser ، Ahmad Department of Pathobiology, Division of Medical Microbiology - School of Public Health - Tehran University of Medical Sciences , Mirbagheri ، Zohre Department of Pathobiology, Division of Medical Microbiology - School of Public Health - Tehran University of Medical Sciences , Masoumi-Asl ، Hossein Department of Neonatal - Faculty of Medicine - Iran University of Medical Sciences , Torabi ، Parisa Food Microbiology Research Center - Tehran University of Medical Sciences , Mirza Babaei ، Mehrnaz Department of Pathobiology, Division of Medical Microbiology - School of Public Health - Tehran University of Medical Sciences
From page
199
To page
207
Abstract
The prevalence of antibiotic resistance has been demonstrated in various food-borne pathogens. Beta-lactam antibiotics are among the first-line antimicrobials that are normally administered in case of gastrointestinal infections. However, Escherichia coli (E. coli) and some other members of Enterobacteriaceae have indicated broad resistance against such antibiotics thanks to extended-spectrum beta-lactamase (ESBL) enzymes. In this research, 216 stool samples have been screened for ESBL-producing E. coli, using phenotypic antibiotic susceptibility tests. ESBL-producing E. coli isolates were further screened for the presence of antibiotic-resistance genes CTX-M, SHV, and TEM. Our isolation experiments resulted in 111 E. coli isolates among which 41 (36.9%) isolates were found as ESBL. Also, 51.2% of the above ESBL isolates harbored blaTEM. Furthermore, 18 (43.9%) and 2 (4.9%) of those ESBL isolates had blaCTX-M and blaSHV genes, respectively. Our results revealed a detectable prevalence of ESBL E. coli in stool samples collected during food outbreaks. Results of such researches can guide how to control the distribution of drug-resistant pathogens in various environments. In this line, the considerable prevalence of ESBL E. coli seems to have originated from the wide administration of various beta-lactam antibiotics.
Keywords
Beta , lactamase , Clavulanic Acid , Drug , Resistant Pathogens , Food , borne infections , Gastroenteritis Symptoms , Klebsiella Pneumonia
Journal title
Cellular, Molecular and Biomedical Reports
Journal title
Cellular, Molecular and Biomedical Reports
Record number
2767543
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