Four Components One-Pot Synthesis of New Thiazoles and Their Biological Screening for Anti-Tuberculosis Activity

Multi heterocyclic ring system shows a wide spectrum of pharmaceutical and biological activities. Novel series of 2-Benzyloxy-5-(2-{N’-[3-(substituted-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-hydrazino}-thiazol-4-yl)-benzoic acid methyl ester derivatives have been synthesized by one-pot condensation of 2-Benzyloxy-5-(2-bromo-acetyl)-benzoic acid methyl ester, thiosemicarbazide and 3-(substituted-phenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde using orthophosphoric acid as a catalyst under mild reaction condition. All the synthesized compounds were screened for their anti-tubercular activity against Mycobacterium tuberculosis H37Rv stains using the Lowenstein-Jensen (L. J.) medium conventional method. Most of these synthesized compounds are found to be active potent against Mycobacterium tuberculosis H37Rv strain. Environmentally benign, multicomponent, rapid, high atom and step economy, facile are the remarkable features of the present one-pot multicomponent protocol.