Synthesis of Functionalized Polyethylene Glycol Coated Metallic Nanoparticles and Their Antimicrobial Application

The present study emphasizes the synthesis of novel polyethylene glycol (PEG) coated metal oxide NanoParticles (NPs) and NanoComposite (NCs). The co-precipitation method was adopted for the synthesis of Fe3O4, Fe-Ni, and Fe-Cu in the presence of PEG. The nanoparticles were characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infra-Red (FT-IR), and X-Ray Diffraction (XRD) techniques. The FT-IR studies proved that PEG with Fe3O4 nanoparticles as well as Fe-Ni and Fe-Cu nanocomposite were bonded together. The average particle sizes of Fe3O4-PEG, Fe-Ni-PEG, and Fe-Cu-PEG nanocomposites were found less than 100nm precisely to be 75.5, 82.8, and 70.2nm respectively as determined by SEM and XRD analyses. Moreover, their functionality for antimicrobial activity against pathogenic microbes including P.aeruginose, Proteus miribilis, Klebsiellatyphi, Staphylococcus aureus, and Saccharomyces cerevisiae was examined. The Fe-Cu-PEG and Fe-Ni-PEGNCs have stronger antibacterial activity compared to Fe3O4-PEG. This study would be helpful for the treatment of bacterial and viral diseases.