Title of article
A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives
Author/Authors
Ahmadi Shourkaei ، Fatemeh School of Chemistry, College of Science - University of Tehran , Ranjbar ، Parviz Rashidi School of Chemistry, College of Science - University of Tehran , Mahdavi ، Mohammad Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute - Tehran University of Medical Sciences , Tuzun ، Burak Plant and Animal Production Department - Technical Sciences Vocational School of Sivas - Sivas Cumhuriyet University , Taslimi ، Parham Department of Chemistry - Faculty of Arts and Sciences - Yozgat Bozok University
From page
1103
To page
1114
Abstract
A facile synthetic route for constructing 2-thioxoquinazolin-4(1H)-one derivative through cyclization reactions using readily available starting materials 2-aminobenzoic acids, alkyl/aryl amines, and carbon disulfide is described. These reactions occur under mild conditions, producing the desired products with good to high yields. Molecular docking was conducted to assess the activities of the 2-thioxoquinazolin-4(1H)-one derivative against breast cancer protein (PDB ID: 1JNX), liver cancer protein (PDB ID: 2H80), and colon cancer protein (PDB ID: 4UYA). Furthermore, an ADME/T analysis was performed to evaluate the impact of these compounds on human metabolism.
Keywords
2 , Thioxoquinazolin , 4(1H) , one Derivative , Cyclization reaction , Molecular Docking , Breast cancer , liver ADME , Tcancer ,
Journal title
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
Journal title
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
Record number
2768290
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